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In clinical trials at the 12 mg dose, researchers documented nausea in 28% of participants, diarrhea in 23%, constipation in 17%, and vomiting in 12%

The GIP receptor component of tirzepatide may actually counterbalance some of the extreme gastric slowing that pure GLP-1 stimulation causes

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The diabetes and obesity epidemics keep growing with each year of sedentary lifestyle and caloric excess in developing nations whose middle classes are expanding rapidly

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As body composition changes on GLP-1 therapy, thyroid-stimulating hormone (TSH) and free T4 levels may fluctuate modestly