In Phase 2 clinical trials, the highest dose (12mg weekly) produced a mean weight loss of -24.2% over 48 weeks
However, the RCT studies, case reports, and the FAERS database case all highlighted that we should be aware of co-administered neuropsychotropic drugs that may associated with SSIBs
Medications to be cautious with: Certain chemotherapy drugs Specific antibiotics like ciprofloxacin High-dose paracetamol Some antipsychotic medications Impact: These drugs can reduce glutathione levels or affect how the body uses it
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It is a major feature and early event in MASLD pathogenesis (29)
The medication still activates GLP-1 receptors