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The apo-peptide GHK (without copper) has reduced or absent activity in many of the contexts where the copper-bound form has been characterized, reflecting the copper-dependent nature of much of the biology

Kim, M., Choi, Y., Kim, H

This duality is due to phenolic compounds, which may generate ROS in the presence of transition metals like copper (128)

Most men tolerate peptide therapy well when dosed appropriately and supervised by a qualified physician, but this requires regular check-ins-not a one-time consultation followed by self-directed use

doi: 10.1016/j.cmet.2017.03.017 96 SalomonDMedaP

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