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These building blocks are assembled with the help of specialized enzymes such as glutamate-cysteine ligase and glutathione synthetase

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So statements that topical AHK-Cu is "well tolerated" rest on the copper-peptide class generally much of it built on GHK-Cu (Pickart & Margolina 2018, PMID 29986520) and on community use, rather than on dedicated AHK-Cu safety study