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Of particular relevance to IGF-1 anabolic research are TSC2 (relieving inhibition of mTORC1, driving protein synthesis) and FoxO transcription factors (inhibiting their nuclear translocation, blocking expression of atrogenes like MuRF1 and atrogin-1 that drive muscle protein breakdown)

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72 The forkhead-associated (FHA) domain and hydrophobic motif (Leu-137-Phe-145-Phe-154) within its adjacent region on FOXK2 are both required for the interaction of FOXKs and DVL2, and the interaction is regulated by DVL phosphorylation

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