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The study utilized white non-thoroughbred male rats weighing 180-200g

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Nonetheless, our observed association between thyroid hormone over-replacement and new-onset AF/Aflutter aligns with a nested casecontrol study of 183,360 patients: compared to low levothyroxine exposure, high and medium exposure was associated with 29% (95% CI 1.231.35) and 8% (95% CI 1.041.11) increased odds of AF, respectively [36]

Then they gently work their way up, and if they run into these side effects along the way, they can slow down that dose before they ultimately get to that higher dose that allows them to achieve their goal