FMT exerts antidepressant effects through multiple mechanisms, including neurotransmitter level modulation, inflammatory marker reduction, gut barrier function improvement, and HPA axis activity regulation (Zhang et al., 2024)
Accordingly, increased bioavailability of GIP and GLP-1 by the dipeptidyl peptidase 4 inhibitor, sitagliptin, promotes anti-inflammatory polarization of M macrophages towards M2 macrophages and reduces mitochondrial reactive oxygen species production [37,38,39]
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