semaglutide for liver disease Novo Nordisk's Wegovy gets accelerated US approval MASH is semaglutide metabolized in the

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These studies were soon followed by a number of phase 2 and phase 3 clinical trials with several different DPP-4 inhibitors, all essentially showing that DPP-4 inhibition was a safe and well-tolerated means of improving glycaemic control in patients with T2DM

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Large-scale randomized controlled trials, including the SUSTAIN and STEP trial programs involving thousands of participants, have not identified immunosuppression as an adverse effect of semaglutide therapy