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Immunofluorescence staining was conducted to assess antioxidant capacity via SOD expression and to evaluate macrophage polarization using CD86 (M1 marker) and CD206 (M2 marker)

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(2) NNMT catalyzes the N-methylation of nicotinamide using SAM as a methyl donor, consuming both substrates in the process

These contaminants stimulate host cells, including gingival macrophages and fibroblasts, leading to inflammation in periodontal tissue and alveolar bone resorption (Xu et al., 2020

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