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247 This decrease is directly related to abnormal chromosome segregation and increased micronucleus formation, suggesting that inactivation of centromere function is the core cause of mitotic defects in senescent cells

Additionally, macrophages derived from SerpinB2 / mice exhibited elevated production of Th1-promoting cytokines and heightened secretion of interferon- (IFN-), a crucial marker of viral infection, as compared to wild-type cells [30]

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Approximately one third of the weight loss corresponded to lean mass reduction