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As a protease inhibitor, A2M reduces inflammation in arthritic joints and helps to deactivate a variety of proteinases that typically degrade joint cartilage

(2023) 9:eade9944

This dual action allows for appetite regulation without compromising postprandial digestion and absorption, minimizing gastrointestinal discomfort such as bloating and nausea, and aligning well with the needs of patients with gastrointestinal dysfunction

Zhou P, Chen C, Patil S, Dong S

Emelianova, A.A., Kuzmin, D.V., Panteleev, P.V., Sorokin, M., Buzdin, A.A., and Ovchinnikova, T.V., Front

Its primary characterized mechanisms include upregulation of growth factor receptors (VEGFR2, EGFR), promotion of angiogenesis through FAK-paxillin pathway activation, and modulation of nitric oxide synthesis