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To address this, we tested NMN in a model of Dox-induced cardiotoxicity in mice, where animals were co-treated with or without NMN in the same 2 2 design, and cardiac function was assessed by -ultrasound imaging (Fig

1, ESM Figs 2, 3)

A control group of about 300 patients took SGLT-2 inhibitors (e.g., canagliflozin, dapagliflozin, empagliflozin), drugs that are comparable to GLP-1 receptor agonists at lowering blood glucose levels

10.1136/jnnp-2012-303433 127 GelosoM

Glucagon-like peptide-1 receptor agonists (GLP-1RA) are effective to treat adult and pediatric populations with type 2 diabetes (T2D) and/or obesity, and they have an established safety profile

[11] Popa-Wagner, A., Agar, E., Kilic, E., Mf, D., Mc, B., Sp, O., Furkan Dasdelen, M., Er, S., Kaplan, B., Celik, S., Caglar Beker, M., Orhan, C., Tuzcu, M., Sahin, N., Mamedova, H., Sylla, S., Komorowski, J., Ojalvo, S., & Sahin, K