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The meta-analysis found that SGLT2 inhibitors were associated with a 10% reduced risk of major adverse cardiovascular events, a 22% reduced risk of heart failure or cardiovascular death, and a 38% risk reduction in a composite of adverse kidney outcomes (Inzucchi 2021)

It is not a medical recommendation

Results tend to be most noticeable when paired with calorie control, strength training, hydration, and regular movement

Its best use case may be as an add-on agent to be used with GLP-1 agonists, and not as a standalone alternative to Tirzepatide

However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions