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The inhibitory effects of peripheral administration of peptide YY(336) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway

However, it is hypothesized that the drug may work by decreasing appetite, slowing down gastric emptying, and potentially influencing the brains reward system

The maximum recommended maintenance dose is 3 mg once daily

Do not rub the injection site afterward

and avoiding spicy, high-fat, or high-fiber foods, particularly during the first few days of therapy

Hold isotretinoin and consult a hepatologist if ALT or AST reaches three times the upper limit of normal [2]