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doi: 10.1542/peds.2019-2528

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Mechanistic Comparison# Dosing Comparison# Tirzepatide Dosing# Tirzepatide uses a unified escalation schedule for both indications: Starting dose: 2.5 mg weekly for 4 weeks Escalation: 2.5 mg increments at minimum 4-week intervals Dose range: 2.5, 5, 7.5, 10, 12.5, 15 mg First therapeutic dose: 5 mg Maximum: 15 mg weekly Supplied as single-dose pre-filled pens with hidden needle design