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In late 2023, the FDA moved BPC-157 to Category 2, citing concerns over impurities and immunogenicity in unregulated batches

If the hemoglobinuria has already subsided and the history is uncertain, one is faced instead with the much wider differential diagnosis of AHA

Due to the potential of GLP-1R antagonists to modulate T-cell regulation and the evidence that enhancing T-cell infiltration can effectively transform cold tumors into hot tumors (2729), it is plausible that combining GLP-1R antagonists with ICIs may synergistically modulate T-cell-mediated immune sensitivity to improve tumor treatment outcomes