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91 Liver diseases have also been linked to oxidative stress

The hepatic parenchymal cells, the hepatocytes, have an immensely broad range of synthetic and catabolic functions, which are summarized in Table 30.1

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Specifically, AMPK can inactivate ACC by phosphorylation, resulting in reduced activity of malonate monoacyl coenzyme A (CoA) and reducing allosteric inhibition of CPT1, thereby enhancing the activity of CPT1, which transports long-chain fatty acids from carnitine to mitochondria for -oxidation [17]