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Indeed, it is known that hydrochlorothiazide can target several ion transporters and enzymes including SLC4A8 , a Na + -dependent Cl /HCO 3 exchanger (NDCBE), SLC26A4 , a Na + -independent Cl /HCO 3 exchanger (Pendrin) and carbonic anhydrases (Pickkers et al., 1999

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Basic physicochemical properties of DNZ-NLPs The polydispersity index (PDI), particle size, and particle surface charge (zeta potential) of B-NLPs and DNZ-NLPs were determined through the dynamic light scattering (DLS) technique, utilizing the Zetasizer instrument (Malvern Instruments Ltd., Worcestershire, UK) at 25 C

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