The core cycle responsible for methylation, known as the folate-methionine cycle, relies on active forms of vitamin B12 (methylcobalamin), folate, and B6 to produce S-adenosylmethionine (SAM)
M.CousinsL.DeakinJ.LennoxB
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It keeps cells resilient under everyday strain, and when dogs are sick, inflamed, or simply older, oxidative stress rises and glutathione is one of the main tools the body uses to buffer the load (Hagen DM, 2019)
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These results are shown in Table 2