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The peptide's combined effect of stimulating new collagen production while suppressing matrix metalloproteinase expression (the enzymes that break down collagen) provides a mechanistically rational approach to photoaging that operates through different pathways than retinoids or sunscreen

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Metabolic pathways: B12 is a cofactor in two critical reactions: Methylmalonyl-CoA mutase: Converts methylmalonyl CoA (from odd-chain fatty acids and some amino acids) into succinyl-CoA, which enters the Krebs (TCA) cycle to make ATP (cellular energy)

New Frontiers in Psoriatic Disease Research, Part I: Genetics, environmental triggers, immunology, pathophysiology, and precision medicine

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