It is both absorbed from food and synthesised from the two amino acids lysine and methionine
Seiler, S
The mRNA levels of BBOX1 , the key enzyme for carnitine synthesis, were not significantly different in the liver and in fasting state muscle
Bielinska K, Radkowski M, Grochowska M, Perlejewski K, Huc T, Jaworska K, Motooka D, Nakamura S, Ufnal M
People with metabolic diseases, such as metabolic syndrome, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (formerly NAFLD), [can also benefit from it] since ALCAR can support fatty acid metabolism, Warner adds
3 Endogenous de novo biosynthesis supplies a critical, regulated source that supports tissue-specific carnitine availability and metabolic adaptation