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Importantly, having GERD or reflux history does not automatically disqualify you from GLP-1 therapymillions of patients with acid reflux use GLP-1 safely with proper management

[17] Knockout studies with GPX1, GPX2, or GPX3 deficient mice showed that cytosolic GPX4 is so far the only glutathione peroxidase that is indispensable for embryonic development and cell survival

They both connect to and turn on GLP-1 receptors, but their shapes have changed, so they work in the body in different ways