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doi: 10.1016/j.spinee.2012.03.030 8 ParkMKSungJKNamKHKimKT

This is the lowest commonly reported off-label starting value

In particular, due to its amphiphilic characteristics, melatonin can diffuse and easily cross all morpho-physiological barriers, such as the placenta or the bloodbrain barrier 8,9 , and it can enter all cells of the body, influencing the function of a variety of tissues 10

Health experts estimate that thousands of people will be eligible when the drug becomes available

doi:10.1177/0022034510375830 6

Though consecutive high-dose pyridoxine intake can lead to peripheral sensory neuropathy and nerve degeneration, these problems are generally reversible when supplementation is stopped 60,61