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Patients with underlying thyroid conditions, pancreatitis history, or renal impairment require robust initial screening

GLP-1s may help reduce persistent, intrusive thoughts about food often referred to as "food noise." The exact mechanism for this effect is not entirely clear but may be linked to how these medications influence hunger and satiety signals in the brain

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Across major studies of semaglutide and tirzepatide, roughly 10% to 15% of patients failed to lose at least 5% of their starting body weight