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The second pathway is gastrointestinal losses

Metabolic Adaptation and Weight Loss Plateaus The body naturally resists sustained weight loss through metabolic adaptation: as you lose weight, your resting metabolic rate decreases, and your body increases hunger hormone production to defend your previous weight

It stimulates POMC neurons (which suppress appetite) and inhibits NPY/AgRP neurons (which stimulate hunger)

Weight loss is actually a side effective of Wellbutrin, and many people appreciate this added benefit of the drug

How to Move Past a Semaglutide Weight-Loss Plateau Once it is clear that weight has stayed the same for a while, small changes can often help progress begin again

These are typically transient and subside over time