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Still, if the change feels distressing or different enough to affect your well-being or relationships, its worth bringing up with your doctor

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However, in a similar study performed to evaluate the effects of pyruvate with increased frequency of dosing (500 mg/kg i.p., 6 days a week) in SOD1 G93A mice, pyruvate was not able to alter the onset of the disease or survival of mice (Esposito et al., 2007)

Clar C, Gill JA, Court R, Waugh N

You may be eating the same, moving your body, doing everything "right," and still watching your body change

63 After 14 days of treatment, the group receiving the combination had a significant improvement in symptoms versus no change in the placebo group