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Unpredictable pharmacology : The dose-response relationship for both efficacy and safety has not been characterised at very low doses, creating uncertainty about what effectsbeneficial or harmfulmight occur

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Blood Pressure-Lowering Effects of GLP-1 Receptor Agonists Exenatide and Liraglutide: A Meta-Analysis of Clinical Trials

Anti-obesity medications such as orlistat, phentermine-topiramate, and naltrexone-bupropion have induced a weight loss of no more than 10%, which is insufficient to prevent the risk of ORCVDs