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In the landmark SURMOUNT-1 trial, participants receiving the highest dose of tirzepatide lost an average of 22.5% of their body weight over 72 weeks, making it one of the most effective pharmaceutical weight loss interventions available (Jastreboff et al., 2022, New England Journal of Medicine )

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Lipotropic nutrients are a class of natural nutrients that play important role in the body's use of fat

Hence, these results suggest that an additional stimulus might be required for inflammasome activation and subsequent processing and secretion of IL-1