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The resulting lactate upregulates SRSF10 via H3K18la, eventually forming a feedback loop involving circMETTL3/METTL3-156aa/LDHA/Lactate/SRSF10 that triggers cytokine storms in sHLH

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Research suggests they might work through sequential and complementary pathways: BPC-157 could provide initial cytoprotection and anti-inflammatory effects, creating a favorable environment for repair, while TB-500 might then promote cellular migration and structural reorganization