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Performed the experiments: FJ CLS FM HC TH

Antibodies specific for ACTL6A (Abcam, ab3882, 1:4000), GCLC (Abcam, ab190685, 1:4000), anti-NRF2 (Cell Signaling Technology, 12721 s, 1:2000), flag-tag (Sigma, F1804, 1:5000), and GAPDH (Proteintech, 10494-1-AP, 1:5000) were purchased from the indicated companies

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Additionally, curcumin restores UV-induced mutant p53 function by modulating B-cell lymphoma 2 Associated X Protein/B-cell lymphoma 2(Bax/Bcl-2)balance, reversing apoptosis resistance and improving mitochondrial homeostasis (Rebel et al., 2012)