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however they do exhibit induction of mRNA encoding the modifier subunit of glutamate-cysteine ligase (Gclm), the rate limiting enzyme in GSH biosynthesis (Bondareva et al., 2007

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This is mechanistically different from injecting recombinant GH itself: a GHRH agonist raises GH indirectly, through the pituitary, so the output remains at least partly subject to the axiss normal regulation including negative feedback from IGF-1 and somatostatin

N Engl J Med (2022) 387(12):106374

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