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The research team reported the following changes in HbA1c at 52 weeks: Orfoglipron 12 mg group: -1.71% Orfoglipron 36 mg group: -1.91% Oral semaglutide 7mg group: -1.23% Oral semaglutide 14mg group: -1.47% The research team confirmed that the study achieved its primary endpoint of non-inferiority, which indicates that the new drug (orfogliprone) is not inferior to the existing drug (oral semaglutide) in clinical trials

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(NEJM, 2023) before beginning your titration

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