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Adv Ther 36(5):10851099 Honvo G, Reginster JY, Rabenda V, Geerinck A, Mkinsi O, Charles A et al (2019b) Safety of symptomatic slow-acting drugs for osteoarthritis: outcomes of a systematic review and meta-analysis

According to the available research, topical peptides such as GHK-Cu, acetyl hexapeptide-3/8, palmitoyl tripeptide-5, and others do not appear to exert any side effects when applied topically

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