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Back in the 1960s, researchers found that -MSH caused caused sexual arousal when administered to rats, which eventually led to the development of -MSH analogues like PT-141, melanotan I, and melanotan II

Senekowitsch, S., Wietkamp, E., Grimm, M., Schmelter, F., Schick, P., Kordowski, A., Sina, C., Otzen, H., Weitschies, W., & Smollich, M

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Corley BT, Carroll RW, Hall RM, Weatherall M, Parry-Strong A, Krebs JD

Mesquita JF, Ramos TF, Mesquita FP, Bastos-Netto JM

Importantly, a substantial proportion of participants had established CKD, lending relevance to these findings within the renally impaired population