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70 Finally, GLP-1 attenuated IL-1 -mRNA expression induced by lipopolysaccharide (a component of Gram-negative bacteria) in rat astrocytes

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It helps maintain muscle mass, keeps hunger in check, and even enhances the release of hormones that promote a feeling of fullness

Activation of the GLP- 1 receptor also prevents beta cell apoptosis

The dehydration risk is very important, and you may not necessarily notice it right away

Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)