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Fermented foods containing probiotics may indirectly support GLP-1 production by promoting a healthy gut microbiome, though robust human evidence remains limited

International Journal of Biochemistry and Cell Biology, 42 (7), 11321141

Joan Bot

Initially, main concerns were receptor-activating activity while recently, downstream effects of GLP-1R and GIPR have been more and more revealed that not only receptor activation promotes cAMP and stimulates insulin releasing, but also other factors (-arrestin recruitment, residence time, etc.) influence receptor internalization, which further elicits long-term effects in vivo

When semaglutide binds to GLP-1 receptors in these reward centers, it reduces the dopamine surge associated with both food and alcohol