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Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial

PGE 2 contributes to pain hypersensitivity and hyperalgesia by lowering pain thresholds and by enhancing nociceptor sensory fiber excitability by activating EP1-EP4 receptors on nociceptors [91,112]

doi: 10.1016/j.cell.2015.02.020

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This stacking effect is not life-threatening, but it can significantly reduce quality of life and, in some cases, lead patients to discontinue one or both medications losing the benefits of treatment

Therefore, besides their glucose-lowering activity, gliptins have an intrinsic manifold cardiovascular impact