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Patients with higher starting BMIs Patients starting at higher BMIs (40+) often need to progress through the full dose escalation to 10mg, 12.5mg, or 15mg for optimal results

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To support the hypothesis that Cyss uptake underlies the expression of these four NRF2 target genes in MSL/CL TNBC, we next examined the correlation of their expression with the expression levels of the SLC7A11 , E-cadherin ( CDH1 ) claudin 3 ( CLDN3 ), and claudin 7 ( CLDN7 ) genes in TNBC patients ( n = 280) of METABRIC cohort [28]

The most common ones is nausea