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AASLD Applauds FDA Approval of First GLP-1 Therapy for MASH, Expanding Use of Popular Weight Loss Drug to Liver Disease

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The high levels of insulin have been shown to reduce the levels of the Insulin-like growth factor (IGF) binding protein, which can tightly bind to IGFs, resulting in excessive free IGF-1 in cells and tissues

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This observation leads to the question of whether supraphysiological stimulation (as occurs with GLP-1RA use) could accelerate the progression of PanIN lesions into PDAC

Perspectives in GLP-1 research: new targets, new receptors