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Briefly, the preproglucagon gene undergoes tissue-specific post-translational modification with the help of specific propeptidase convertase (PC1/3) to produce two variants of GLP-1, the amidated GLP-1 [736], and the glycine-extended GLP-1 [737] in the ileum and hypothalamus (Zheng et al., 2024)

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Starting at a low dose and increasing slowly gives your body time to adapt

Semaglutide works by mimicking the effects of the hormone GLP-1, which plays a crucial role in controlling appetite, food intake, and blood sugar levels

T., Laven, J

OASIS 1 trial (oral semaglutide Rybelsus) 50