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The observation acquires sharper edges when placed beside recent work showing that food odor induces cephalic phase insulin release in lean and diet-induced obese male mice

Thus, cotadutide, via direct hepatic (GcgR) and extrahepatic (Glp-1R) effects, exerts multifactorial improvement in liver function and is a promising therapeutic option for the treatment of steatohepatitis

For example, both triple agonists retatrutide and HM15211 have shown promising results

Nauck M, Frid A, Hermansen K, Shah NS, Tankova T, Mitha IH et al

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The Novo Nordisk Foundation Center for Protein Research is supported financially by the Novo Nordisk Foundation (grant number NNF14CC0001)