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Treating only the heel without addressing the chain above it is one of the main reasons people plateau with standard care

doi: 10.1001/jamaophthalmol.2024.1822

The dosing context below summarizes published study arms and common research-planning structures

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In SARS-CoV-2, TMPRSS2 facilitates cellcell fusion in the absence of furin-mediated cleavage at the S1/S2 site, and high TMPRSS2 expression is required to cleave S2 and activate the fusion mechanism for efficient entry 26,27