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However, increasing cell compliance or reducing matrix stiffness suppresses energetic costs, blinding MDA-MB-231 cells to hydraulic resistance and enabling them to navigate through high-resistance migratory paths that would otherwise demand more energy [201]

Updated: As of late Nov

Moreover, there are several paradigmatic conditions such as Down syndrome, phenylketonuria, and various lipidoses (Scriver et al., 1989) where the metabolic abnormalities are expressed in both neural and peripheral tissues, but the functional consequences are most profound in the central nervous system (CNS)

Ronen O, Robbins KT, Olsen KD, Shaha AR, Randolph GW, Nixon IJ, Zafereo ME , Hartl DM, Kowalski LP, Rodrigo JP, Coca-Pelaz A, Mkitie AA, Vander Poorten V, Sanabria A, Angelos P, Rinaldo A, Ferlito A

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Chronic renal insufficiency complications in cats include renal secondary hyperparathyroidism, hypertension, hypokalemia, proteinuria, anorexia, and anemia