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Research shows that autoantibodies, such as anti-TPO, ANA, and anti-ENA, provide valuable early indicators of disease risk, enabling clinicians to intervene before overt symptoms develop

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A review by Cardinali highlights melatonins potential in counteracting neurodegeneration and frailty in the elderly, noting melatonins excellent safety profile and low toxicity even at high doses ( Melatonin supplementation in older adults must be timed correctly to avoid phase shifts that could worsen circadian timing if misused