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SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: implications for cell survival after irradiation

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The structure included four intramolecular hydrogen bonds, which contribute to its stability

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Room temperature peptide stability drops dramatically, with significant degradation occurring within hours rather than weeks

Researchers should establish baseline control systems without peptide exposure and, when appropriate, use structurally related fragments or analogs to differentiate specific molecular effects from background activity