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The exact relationship between flushing and MS remains somewhat of a mystery

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Similarly, SM102, a novel long-acting GLP-1RA structurally related to semaglutide, demonstrated robust efficacy in the db/db mouse model

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However, some gout patients with elevated 24-hour urine uric acid, as described in Japanese cohorts, have renal uric overload due to intestinal ABCG2 dysfunction without uric acid overproduction ( Figure 1 - 5 )

Altogether, these data support a pathogenicity mechanism where variants can disrupt transporter gating