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The flexibility of this signaling pathway and multiple regulatory mechanisms make necroptosis potentially bidirectional in tumor microenvironment remodeling, chemotherapeutic resistance and immune escape, namely, it can exert both antitumor and pro-tumor effects depending on the context (131)

Subsequently, cDNA encoding the NHR-49 isoform C, with an N-terminal 6x-histidine (His) tag, was obtained from GENEWIZ and inserted downstream of the pept-1 promoter and upstream of the YFP tag to create the pLMT2 expression vector

Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

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32 Fibrates, statins, and omega-3 fatty acids produce modest improvement in AST levels but do not offer advantages over weight loss and increased physical activity