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In obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and lowering NAD+ availability [2]

Gastrointestinal Distress Moderate or severe GI distress is another sign of low B12

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Researchers continue to investigate how NNMT inhibition affects intracellular signaling, energy utilization, and the complex biochemical pathways involved in maintaining cellular homeostasis

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