ada tirzepatide SURMOUNTs obstructive sleep apnea, what's next in advancing GLP-1s? ada tirzepatide Pharmacogenomics of Tirzepatide:

A multimodal approach targeting gut motility, sensory processing, and neuroimmune regulation is essential

If you've been struggling with weight despite doing the right things, your body may be working against you and that's something we can actually measure and address

Polito R, La Torre ME, Moscatelli F, Cibelli G, Valenzano A, Panaro MA, Monda M, Messina A, Monda V, Pisanelli D, Sessa F, Messina G, Porro C (2023) The ketogenic diet and neuroinflammation: the action of beta-hydroxybutyrate in a microglial cell line

Materials and methods Clinical trial design This was a phase Ib, single centre, open-label study (NCT03350191, ClinicalTrials.gov) with 20 days once daily repeated subcutaneous doses of SAR425899 at 2 different dose regimens (A and B) in overweight to obese T2D patients

Less rigorous than a prospective randomised trial but useful for generating preliminary evidence

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