Weschawalit et al
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A phase 1 study of pegylated recombinant arginase (PEG-BCT-100) in combination with systemic chemotherapy (capecitabine and oxaliplatin)[PACOX] in advanced hepatocellular carcinoma patients
Increase after 2-4 weeks if tolerated well and results warrant more
Various GSH-cleavable linkages, including disulfide bond, succinimide thioether bond, and selenite bond, have been commonly utilized to create redox-responsive drug delivery systems [36, 37]
[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Ben-Shachar R., Chen Y., Luo S., Hartman C., Reed M., Nijhout H.F